Essential Role of CD11a in CD8 + T-Cell Accumulation and Activation in Adipose Tissue
نویسندگان
چکیده
منابع مشابه
Essential role of CD11a in CD8+ T-cell accumulation and activation in adipose tissue.
OBJECTIVE T cells, particularly CD8(+) T cells, are major participants in obesity-linked adipose tissue (AT) inflammation. We examined the mechanisms of CD8(+) T-cell accumulation and activation in AT and the role of CD11a, a β2 integrin. APPROACH AND RESULTS CD8(+) T cells in AT of obese mice showed activated phenotypes with increased proliferation and interferon-γ expression. In vitro, CD8(...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2014
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.113.302077